Current Yellow fever situation in the Americas: call for strengthened surveillance and vaccination efforts in enzootic and newly affected areas
Yellow fever activity in the Americas Region has intensified over the past two years, with 2025 recording the highest annual number of confirmed cases since 2020 (Figure 1). This resurgence follows major outbreaks reported in 2017 and 2018 and is notable for cases in areas without a historical record of transmission, including outside of the Amazon Region. Preventing further spread of the virus requires maintaining strong surveillance systems, sustaining high vaccination coverage in populations living in high-risk areas, and ensuring a timely detection and coordinated response.

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