2025 AHA/ACC blood pressure guideline and HEARTS 2.0: implications for the future evolution of integrated cardiovascular–kidney–metabolic care in the Americas

Hypertension is the leading modifiable risk factor for cardiovascular disease. In 2025, two major evidence-based frameworks evolved in parallel: HEARTS 2.0, an implementation-oriented clinical pathway for integrated cardiovascular–kidney–metabolic (CKM) care through primary health care, and the updated American Heart Association/American College of Cardiology Blood Pressure Guideline, one of the world's leading hypertension guidelines.

HEARTS in the Americas 2026

Cardiovascular diseases continue to be the leading cause of death in the Region of the Americas, accounting for more than 2.2 million deaths annually, and pose a critical challenge to health systems, economic development, and social equity. The absolute number of cases has continued to rise, while the decline in mortality has slowed since the mid-2010s, jeopardizing progress toward the goal of reducing premature mortality from noncommunicable diseases by 30% by 2030.

Transforming vaccination brigades with an offline digital app: evidence from the Peruvian Amazon, 2025

Objectives: To compare the performance of paper-based record-keeping versus an offline digital app when used by vaccination brigades in Indigenous communities in the Peruvian Amazon in 2025, considering four dimensions: operational efficiency, data quality, usability, and acceptance. Secondarily, to identify distinct user profiles. 

Making primary health care work better: the HEARTS 2.0 opportunity to integrate cardiovascular–kidney–metabolic care

In this special issue of the Revista Panamericana de Salud Pública/Pan American Journal of Public Health, we bring together a collection of papers that reflects the evolution of HEARTS in the Americas and the growing experience accumulated by countries in improving the prevention and management of noncommunicable diseases (NCDs) through primary health care (PHC). Collectively, these contributions demonstrate that advancing PHC is no longer an aspirational goal but an increasingly achievable reality.

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