Implementation research is a crucial component of effective public health and clinical policies and programs. It promotes the generation and use of health policy and systems research (HPSR) as a means to improve health and health systems, and is particularly effective in low- and middle-income countries. HPSR, including implementation research, has been promoted by the World Health Organization (WHO) as an effective mechanism with which to identify gaps in a health system’s capacity, efficient functioning, and sustainable use of funds. 

This special issue of the Pan American Journal of Public Health on “HIV/AIDS prevention, care and treatment in the Region of the Americas: achievements, challenges and perspectives” presents the current response to HIV/AIDS in the Region with a focus on three main areas: HIV prevention, HIV care and treatment, and the elimination of mother-to-child transmission of HIV and congenital syphilis.    

Though the devastating health effects of tobacco use are well known, tobacco’s negative repercussions extend well beyond the obvious health outcomes. Tobacco consumption creates a significant economic burden on societies because of both the high costs of health care and the associated lost productivity. In addition, tobacco use contributes to health inequalities and exacerbates poverty within and between countries through the diversion of resources away from food and other essential needs as well as through foregone income.

Rapid climate change poses direct and unprecedented challenges to human health on a global scale. These include the burden of disease from environmental risks—expected to rise steadily over the coming years—and direct and indirect effects on human health due to disruptions and shifts in services provided by ecosystems.

Recent decades have witnessed major and alarming changes in nutritional status and trends at the global level. These include a double burden of disease in which some 50 million children under age 5 suffer from wasting or acute malnutrition while 41 million others are overweight or obese. In the Americas, trends similar to, and in some cases worse than, those include high rates of childhood anemia and stunting alongside obesity rates as high as 20-25% in children and adolescents.

Health regulation is regarded as one of public health’s basic functions.

The Region of the Americas, together with the rest of the world, is preparing to face the major challenges presented by the post-2015 sustainable development agenda, whose 17 objectives include health and well-being, the reduction of inequity, and action on a wide range of social and environmental determinants of health.